Identification of Molecular Biomarkers for Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Identification of molecular biomarkers for multiple sclerosis.
Multiple sclerosis is a demyelinating disease of the central nervous system with a presumed autoimmune etiology. Previous microarray analyses identified conserved gene expression signatures in peripheral blood mononuclear cells of patients with autoimmune diseases. We used quantitative real-time polymerase chain reaction analysis to identify a minimum number of genes of which transcript levels ...
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Roland Martina, Bibiana Bielekovab, Reinhard Hohlfeldc and Ursula Utzd,∗ Catalan Institute for Research and Advanced Studies and Unidad de Neuroimmunologia Clinica, Hospital Universitari Vall d’Hebron, Barcelona, Spain Department of Neurology, Waddel Center for MS, University of Cincinnati & The Neuroscience Institute, Cincinnati, OH, USA Department of Neuroimmunology, Max-Planck-Institute of N...
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Many studies have investigated misregulation of miRNAs relevant to multiple sclerosis (MS) pathogenesis. Abnormal miRNAs can be used both as candidate biomarker for MS diagnosis and understanding the disease miRNA-mRNA regulatory network. In this comprehensive study, misregulated miRNAs related to MS were collected from existing literature, databases and via in silico prediction. A multi-staged...
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Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease ac...
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Recent years have witnessed impressive advances in the use of magnetic resonance imaging (MRI) for the assessment of patients with multiple sclerosis (MS). Complementary to the clinical evaluation, conventional MRI provides crucial pieces of information for the diagnosis of MS. However, the correlation between the burden of lesions observed on conventional MRI scans and the clinical manifestati...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2007
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2007.060147